Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
Identifieur interne : 001241 ( Main/Exploration ); précédent : 001240; suivant : 001242Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
Auteurs : Abhiram Pushparaj [Canada] ; Clement Hamani [Canada] ; Wilson Yu [États-Unis] ; Damian S. Shin [États-Unis] ; Bin Kang [Canada] ; José N. Nobrega [Canada] ; Bernard Le Foll [Canada]Source :
- Neuropsychopharmacology [ 0893-133X ] ; 2012.
Abstract
Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.
Url:
DOI: 10.1038/npp.2012.235
PubMed: 23249816
PubMed Central: 3572467
Affiliations:
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In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Pushparaj, Abhiram" sort="Pushparaj, Abhiram" uniqKey="Pushparaj A" first="Abhiram" last="Pushparaj">Abhiram Pushparaj</name></noRegion><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Kang, Bin" sort="Kang, Bin" uniqKey="Kang B" first="Bin" last="Kang">Bin Kang</name><name sortKey="Le Foll, Bernard" sort="Le Foll, Bernard" uniqKey="Le Foll B" first="Bernard" last="Le Foll">Bernard Le Foll</name><name sortKey="Le Foll, Bernard" sort="Le Foll, Bernard" uniqKey="Le Foll B" first="Bernard" last="Le Foll">Bernard Le Foll</name><name sortKey="Le Foll, Bernard" sort="Le Foll, Bernard" uniqKey="Le Foll B" first="Bernard" last="Le Foll">Bernard Le Foll</name><name sortKey="Nobrega, Jose N" sort="Nobrega, Jose N" uniqKey="Nobrega J" first="José N" last="Nobrega">José N. Nobrega</name><name sortKey="Nobrega, Jose N" sort="Nobrega, Jose N" uniqKey="Nobrega J" first="José N" last="Nobrega">José N. Nobrega</name></country><country name="États-Unis"><noRegion><name sortKey="Yu, Wilson" sort="Yu, Wilson" uniqKey="Yu W" first="Wilson" last="Yu">Wilson Yu</name></noRegion><name sortKey="Shin, Damian S" sort="Shin, Damian S" uniqKey="Shin D" first="Damian S" last="Shin">Damian S. Shin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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